IRL-1620
| CAS No. | 142569-99-1 | Cat. No. | BCP09112 |
| Name | IRL-1620 | ||
| Synonyms | SPI-1620; IRL1620; IRL 1620; | ||
| Formula | C86H117N17O27 | M. Wt | 1820.95 |
| Description | IRL-1620, also known as SPI-1620, is an endothelin B receptor agonist. SPI-1620 is a highly selective peptide agonist of the endothelin-B receptor. Endothelin B receptor agonist SPI-1620 binds to endothelin-B receptors on endothelial cells in tumor blood vessels, which, unlike the angioarchitecture of normal blood vessels, are relatively devoid of smooth muscle. This agent may induce a transient, selective increase in blood flow to a tumor, which may result in an increase in the delivery of anticancer agents to the tumor and, so, an increase in anticancer agent efficacy. | ||
| Pathways | GPCR/G Protein | ||
| Targets | Endothelin Receptor | ||
Structure
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