(-)-石杉碱甲
| CAS号 | 102518-79-6 | 货号 | BCP08891 |
| 中文名 | (-)-石杉碱甲 | ||
| 英文名 | (-)-Huperzine A | ||
| 中文别名 | |||
| 英文别名 | (-)-Selagine; | ||
| 分子式 | C15H18N2O | 分子量 | 242.32 |
| 生物活性 | (-)-Huperzine A is the more potent stereoisomer of racemic (±)-Huperzine A (sc-218582) preparations, an approximately 38-fold more potent inhibitor of AChE than (+)-Huperzine A. Both the (-) and (+) stereoisomers also demonstrate NMDA receptor antagonism with similar affinity. Pretreatment of cerebral neuronal cells with (-)-Huperzine A confers protection against glutamate-mediated Ca2+ influx and excitotoxicity, moderated by blockade of NMDA-associated ion channel activity. | ||
| 信号通路 | Neuro Signaling Pathway | ||
| 靶 点 | AChE | ||
结构式
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