(-)-Huperzine A
| CAS No. | 102518-79-6 | Cat. No. | BCP08891 |
| Name | (-)-Huperzine A | ||
| Synonyms | (-)-Selagine; | ||
| Formula | C15H18N2O | M. Wt | 242.32 |
| Description | (-)-Huperzine A is the more potent stereoisomer of racemic (±)-Huperzine A (sc-218582) preparations, an approximately 38-fold more potent inhibitor of AChE than (+)-Huperzine A. Both the (-) and (+) stereoisomers also demonstrate NMDA receptor antagonism with similar affinity. Pretreatment of cerebral neuronal cells with (-)-Huperzine A confers protection against glutamate-mediated Ca2+ influx and excitotoxicity, moderated by blockade of NMDA-associated ion channel activity. | ||
| Pathways | Neuro Signaling Pathway | ||
| Targets | AChE | ||
Structure
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