卡奈替尼两盐酸盐
| CAS号 | 289499-45-2 | 货号 | BCP01902 |
| 中文名 | 卡奈替尼两盐酸盐 | ||
| 英文名 | Canertinib dihydrochloride | ||
| 中文别名 | |||
| 英文别名 | Canertinib 2HCl;CI-103;CI 103;CI103; | ||
| 分子式 | C24H27Cl3FN5O3 | 分子量 | 558.86 |
| 生物活性 | Canertinib Dihydrochloride is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities. Canertinib binds to the intracellular domains of epidermal growth factor receptor tyrosine kinases (ErbB family), irreversibly inhibiting their signal transduction functions and resulting in tumor cell apoptosis and suppression of tumor cell proliferation. This agent also acts as a radiosensitizing agent and displays synergistic activity with other chemotherapeutic agents. | ||
| 上下游产品 | 267243-28-7（卡奈替尼） | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
| 靶 点 | EGFR HER2 | ||
结构式
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