Fluorouracil

Description	Fluorouracil, also known as 5-Fluorouracil and 5-FU, is a medication which is used in the treatment of cancer. It is a suicide inhibitor and works through irreversible inhibition of thymidylate synthase. It belongs to the family of drugs called the antimetabolites. It is also a pyrimidine analog. Fluorouracil has been given systemically for anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers (especially head and neck cancers). It has also been given topically (on the skin) for actinic keratoses, skin cancers and Bowen's disease.
Pathways	Cell Cycle/DNA Damage
Targets	Antimetabolite

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