卢帕他定
| CAS号 | 158876-82-5 | 货号 | BCP02444 |
| 中文名 | 卢帕他定 | ||
| 英文名 | Rupatadine | ||
| 中文别名 | 鲁帕他定; | ||
| 英文别名 | UR-12592;UR 12592;UR12592;Rupafi; | ||
| 分子式 | C26H26ClN3 | 分子量 | 415.96 |
| 生物活性 | Rupatadine inhibits both platelet-activating factor (PAF) and histamine (H1) effects through its interaction with specific receptors. Rupatadine competitively inhibits histamine-induced guinea pig ileum contraction (pA2 = 9.29 ± 0.06) without affecting contraction induced by ACh, serotonin or leukotriene D4(LTD4). It also competitively inhibits PAF-induced platelet aggregation in washed rabbit platelets (WRP) (pA2= 6.68 ± 0.08) and in human platelet-rich plasma (HPRP) (IC50 = 0.68 μM), while not affecting ADP- or arachidonic acid-induced platelet aggregation.In another study, it is reported rupatadine and loratadine shows similar inhibitory effect on histamine and TNF-α release, whereas SR-27417A only exhibits inhibitory effect against TNF-α. | ||
| 上下游产品 | 182349-12-8（富马酸卢帕他定） | ||
| 信号通路 | Neuro Signaling Pathway GPCR/G Protein | ||
| 靶 点 | 5 HT Receptor/Serotonin Receptor | ||
结构式
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