胰岛素样生长因子-1 受体拮抗剂
CAS号 | 468740-43-4 | 货号 | BCP02116 |
中文名 | 胰岛素样生长因子-1 受体拮抗剂 | ||
英文名 | BMS-536924 | ||
中文别名 | |||
英文别名 | BMS536924;BMS 536924; | ||
分子式 | C25H26ClN5O3 | 分子量 | 479.96 |
生物活性 | BMS-536924 also inhibits FAK and Lck with IC50 of 150 nM and 341 nM, respectively. BMS-536924 inhibits cellular proliferation and disrupts Akt and MAPK phosphorylation.BMS-536924 inhibits IGF-I-stimulated IGF-1R signaling in MCF10A cells and blocks constitutive IGF-1R activity in CD8-IGF-1R-MCF10A. Preincubation of MCF10A cells with 1 μM BMS-536924 completely blocks the ability of IGF-I to stimulate IGF-1R phosphorylation. IGF-I stimulation results in increased phosphorylation of ERK1/2, GSK3β, and Akt. BMS-536924 inhibits this ligand-induced phosphorylation. | ||
信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
靶 点 | Insulin Receptor IGF1R |
结构式
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