YO-01027
| CAS No. | 209984-56-5 | Cat. No. | BCP02556 |
| Name | YO-01027 | ||
| Synonyms | Dibenzazepine;DBZ;LY 411575;LY411575;LY-411575; | ||
| Formula | C26H23F2N3O3 | M. Wt | 479.48 |
| Description | Increasing concentrations of YO-01027 administered to APPL- or Notch-expressing cells leads to the progressive accumulation of APPL CTF fragments and a decrease in NICD production in a strictly dose-dependent manner. [1] 10 μM of YO-01027 reduces breast cancer stem cells (BCSC) number and activity. [2] A recent research indicates YO-01027 impairs mucin protein MUC16 biosynthesis in a concentration-dependent manner in undifferentiated cells at both preconfluent and confluent stages through Notch inhibition, but not in postmitotic stratified cells. | ||
| Pathways | Protease/Metabolic Enzyme Neuro Signaling Pathway Wnt/Stem Cell | ||
| Targets | Gamma secretase Notch | ||
Structure
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