达比加群酯

  • 化学数据
CAS号 211915-06-9 货号 BCP02864
中文名 达比加群酯
英文名 Dabigatran etexilate
中文别名
英文别名 Prazaxa;BIBR 1048;BIBR-1048;BIBR1048;
分子式 C34H41N7O5 分子量 627.73
  • 用途
生物活性 Dabigatran selectively and reversibly inhibits human thrombin (Ki: 4.5 nM) as well as thrombin-induced platelet aggregation (IC50: 10 nM), while showing no inhibitory effect on other platelet-stimulating agents. Dabigatran selectively and reversibly inhibits human thrombin (Ki: 4.5 nM) as well as thrombin-induced platelet aggregation (IC50: 10 nM), while showing no inhibitory effect on other platelet-stimulating agents. Dabigatran inhibits thrombin generation in platelet-poor plasma (PPP) with IC50 of 0.56 μM, measured as the endogenous thrombin potential (ETP). Dabigatran demonstrates concentrationdependent anticoagulant effects in various species in vitro, doubling the activated partial thromboplastin time (aPTT), prothrombin time (PT) and ecarin clotting time (ECT) in human PPP at concentrations of 0.23, 0.83 and 0.18 μM, respectively.
信号通路 Protease/Metabolic Enzyme 
靶 点 Thrombin 

结构式

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