齐多夫定
| CAS号 | 30516-87-1 | 货号 | BCP03622 |
| 中文名 | 齐多夫定 | ||
| 英文名 | Zidovudine | ||
| 中文别名 | |||
| 英文别名 | BW A509U; BWA 509U; BWA-509U; BWA509U;Azidothymidine;AZT;ZDV;Retrovir; | ||
| 分子式 | C10H13N5O5 | 分子量 | 267.24 |
| 生物活性 | Zidovudine (Retrovir) is a nucleoside analog reverse transcriptase inhibitor (NRTI), a type of antiretroviral drug used for the treatment of HIV/AIDS. Zidovudine (Retrovir) is an analog of thymidine.Like other reverse transcriptase inhibitors, Zidovudine (Retrovir) works by inhibiting the action of reverse transcriptase, the enzyme that HIV uses to make a DNA copy of its RNA. Reverse transcription is necessary for production of the viral double-stranded DNA, which is subsequently integrated into the genetic material of the infected cell. The triphosphate form also inhibits DNA polymerase used by human cells to undergo cell division, but has approximately 100-fold greater affinity for viral reverse transcriptase. | ||
| 信号通路 | Microbiology/Virology | ||
| 靶 点 | Reverse Transcriptase HIV | ||
结构式
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