T0901317
| CAS号 | 293754-55-9 | 货号 | BCP03658 |
| 中文名 | T0901317 | ||
| 英文名 | T0901317 | ||
| 中文别名 | |||
| 英文别名 | T-0901317;T 0901317; T-1317; T1317; T 1317; TO-91317; TO 901317; TO 901317; TO-091317; TO 091317; TO091317; | ||
| 分子式 | C17H12F9NO3S | 分子量 | 481.33 |
| 生物活性 | T0901317 acts through LXR and in concert with its RXR heterodimerization partner induces the expression of the ABCA1 reverse cholesterol transporter. T0901317 upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism.T0901317 displays an EC50 of ~ 5 μM for activation of bile acid farnesoid X receptors (FXRs), 10-fold more potent than natural FXR ligand chenodeoxycholic acid. T0901317, is also a high-affinity ligand for the xenobiotic receptor pregnane X receptor (PXR). T0901317 binds and activates PXR with the same nanomolar potency with which it stimulates LXR activity. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | FXR LXR | ||
结构式
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