盐酸氨溴索

  • 化学数据
CAS号 23828-92-4 货号 BCP04490
中文名 盐酸氨溴索
英文名 Ambroxol hydrochloride
中文别名
英文别名 Ambroxol HCl;NA-872; NA872; NA 872;
分子式 C13H19Br2ClN2O 分子量 414.56
  • 用途
生物活性 Ambroxol inhibits Na+ channels in sensory neurons. The potency for tonic block of TTX-r channels is relatively high. Ambroxol affects the Na+ current kinetics of TTX-r and TTX-s channels differently. In CNaIIA cells, the compound behaves like a charged local anesthetic: the block is dependent on stimulus number and increases with higher frequencies in a train of depolarizing stimuli. In CNaIIA cells, ambroxol inhibits inactivated channels 5.5-fold more potently than resting channels. The corresponding factor for TTX-r channels is only 3.3.Ambroxol inhibits the release of histamine, leukotrienes and cytokines from human leukocytes and mast cells.
信号通路 Others Pathway 
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结构式

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