MK-0752
| CAS No. | 471905-41-6 | Cat. No. | BCP05305 |
| Name | MK-0752 | ||
| Synonyms | MK0752;MK 0752; | ||
| Formula | C21H21ClF2O4S | M. Wt | 442.91 |
| Description | MK-0752 is identified as a moderately potent γ-secretase inhibitor, which reduces Aβ40 in a dose-dependent manner with an IC50 of 5 nM in human SH-SY5Y cells. In vitro, MK-0752 blocks Notch-intracellular domain (ICD) cleavage and its subsequent nuclear translocation. | ||
| Pathways | Protease/Metabolic Enzyme Neuro Signaling Pathway Wnt/Stem Cell | ||
| Targets | Gamma secretase | ||
Structure
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