马来酸氟伏沙明

  • 化学数据
CAS号 61718-82-9 货号 BCP06470
中文名 马来酸氟伏沙明
英文名 Fluvoxamine maleate
中文别名
英文别名 MK-264;MK264;MK 264;
分子式 C19H25F3N2O6 分子量 434.41
  • 用途
生物活性 Fluvoxamine (maleate) is the maleate salt form of fluvoxamine, which is effective in inhibiting 5-HT uptake by blood platelets and brain synaptosomes. The antagonism by fluvoxamine of the reserpine-induced lowering of the pentamethylenetetrazole convulsive threshold can be regarded as due to an effect upon 5-HT uptake. In contrast to the effects of desmethylimipramine and imipramine, no stimulatory effects are found in rats when rapidly acting reserpine-like compounds are given following a dose of fluvoxamine . fluvoxamine appears to improve combat-related PTSD symptoms but not depressive symptoms. The high attrition rate and lack of a placebo group limits the conclusions of our study. Controlled studies of fluvoxamine in the treatment of PTSD are warranted. Fluvoxamine was less potent at decreasing ethanol self-administration when food was available concurrently versus when ethanol was available in isolation [ED50: 4.0 (2.7-5.9) and 5.1 (4.3-6.0)]. Effects on food were similar under e
信号通路 Neuro Signaling Pathway GPCR/G Protein 
靶 点 5 HT Receptor/Serotonin Receptor SSRI 

结构式

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