阿卡地新

  • 化学数据
CAS号 2627-69-2 货号 BCP06900
中文名 阿卡地新
英文名 Acadesine
中文别名
英文别名 GP 1 110; ARA100; ARA-100; ARA 100; SCH-900395; SCH 900395; SCH900395; AICA ribofuranoside;AICAR; AICA-riboside;
分子式 C9H14N4O5 分子量 258.23
  • 用途
生物活性 AICAR is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia[2] and may have applications in treating other disorders such as diabetes. Acadesine is an adenosine regulating agent developed by PeriCor Therapeutics and licensed to Schering-Plough in 2007 for phase III studies. The drug is a potential first-in-class agent for prevention of reperfusion injury in CABG surgery. Schering began patient enrollment in phase III studies in May, 2009. The trial was terminated in late 2010 based on an interim futility analysis.
信号通路 PI3K/Akt/mTOR Epigenetics 
靶 点 AMPK 

结构式

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