盐酸度洛西汀
| CAS号 | 136434-34-9 | 货号 | BCP06975 |
| 中文名 | 盐酸度洛西汀 | ||
| 英文名 | Duloxetine HCl | ||
| 中文别名 | 度洛西林盐酸盐; | ||
| 英文别名 | Duloxetine hydrochloride; | ||
| 分子式 | C18H20ClNOS | 分子量 | 333.88 |
| 生物活性 | Duloxetine Hydrochloride is the hydrochloride salt of duloxetine, a fluoxetine derivative belonging to the class of selective serotonin (5-HT) and norepinephrine (NE) reuptake inhibitors (SSNRIs) and exhibiting antidepressant activity. Duloxetine selectively prevents the reuptake of 5-HT and NE via transporter complexes on the pre-synaptic membrane, thereby increasing the level of these neurotransmitters within the synaptic cleft. As a result, this agent potentiates serotonergic and noradrenergic activities in the central nervous system, and alleviates depression and neuropathy sensations, such as pain and tingling. Furthermore, duloxetine does not show significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and gamma-aminobutyric acid (GABA) receptors. | ||
| 上下游产品 | 116539-59-4（度洛西汀） 116539-60-7（R-(-)-度洛西汀） 116817-11-9（(RS)-盐酸度洛西汀） | ||
| 信号通路 | Neuro Signaling Pathway | ||
| 靶 点 | SSRI | ||
结构式
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