米罗那非
| CAS号 | 862189-95-5 | 货号 | BCP07740 |
| 中文名 | 米罗那非 | ||
| 英文名 | Mirodenafil | ||
| 中文别名 | |||
| 英文别名 | SK3530;SK-3530;SK 3530; | ||
| 分子式 | C26H37N5O5S | 分子量 | 531.67 |
| 生物活性 | Mirodenafil is a newly developed oral phosphodiesterase type 5 inhibitor. Mirodenafil, in doses of 50 or 100 mg, significantly improved erectile function and were well tolerated in a representative population of Korean men with broad-spectrum ED of various etiologies and severities [1]. The concurrent administration of mirodenafil with alcohol was not associated with clinically significant hemodynamic changes in these healthy male volunteers in Korea. The pharmacoki-netics of mirodenafil were not significantly altered by this concurrent administration. Mirodenafil administered with alcohol had a tolerability profile comparable to that of mirodenafil alone . In these healthy Korean male volunteers, the coadministration of ketoconazole and rifampicin resulted in significant changes in systemic exposure to mirodenafil. | ||
| 上下游产品 | 862189-96-6（米罗那非二盐酸盐） | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | Phosphodiesterase/PDE | ||
结构式
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