Way255348
  • 化学数据
CAS号 872141-23-6 货号 BCP21063
中文名 Way255348
英文名 Way255348
中文别名
英文别名 WAY-255348; WAY 255348;
分子式 C16H14FN3O 分子量 283.3
  • 用途
生物活性 WAY-255348 is a potent nonsteroidal progesterone receptor (PR) antagonist. WAY-255348 inhibits the activity of progesterone. WAY-255348 achieves antagonist activity by binding to and subsequently preventing progesterone-induced nuclear accumulation, phosphorylation and promoter interactions of the PR. WAY-255348 bound PR conformation was similar to that of a progesterone agonist-bound PR and distinct from steroidal antagonist-bound PR conformations. WAY-255348 inhibits PR action through a novel molecular mechanism that is distinct from previously studied PR modulators and may be a useful tool to further understanding of PR signaling pathways.
信号通路 Hormone Pathay 
靶 点 Progesterone Receptor 

结构式

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