TAK-632
CAS号 | 1228591-30-7 | 货号 | BCP08426 |
中文名 | TAK-632 | ||
英文名 | TAK-632 | ||
中文别名 | |||
英文别名 | TAK 632; TAK 632; | ||
分子式 | C27H18F4N4O3S | 分子量 | 554.52 |
生物活性 | TAK-632 is a potent pan-RAF inhibitor with favorable in vitro activity (BRAF(V600E) IC50, 2.4 nM; BRAF(wt), 8.3 nM; CRAF, 1.4 nM; pMEK (A375) IC50, 12 nM; pMEK (HMVII), 49 nM; V/B ratio. In addition, TAK-632 was shown preclinically to be a selective kinase inhibitor targeting pan-RAF kinase activity by testing against a panel of kinases. In both A375 (BRAFV600E) and HMVII (NRASQ61K) xenograft models in rats, TAK-632 demonstrated regressive antitumor efficacy by twice daily, 14-day repetitive administration without significant body weight loss | ||
信号通路 | Cell Cycle/DNA Damage MAPK Pathway Epigenetics | ||
靶 点 | Aurora Raf |
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服:
- 全国免费电话:400-099-8200
瀚香生物(Biochempartner) 的所有产品和服务仅用于科学研究,禁止用于人体和治疗!