ABT-737
| CAS号 | 852808-04-9 | 货号 | BCP01725 |
| 中文名 | ABT-737 | ||
| 英文名 | ABT-737 | ||
| 中文别名 | |||
| 英文别名 | ABT737;ABT 737; | ||
| 分子式 | C42H45ClN6O5S2 | 分子量 | 813.43 |
| 生物活性 | ABT-737 shows low activity to Bcl-B and no effects to Mcl-1 and BFL-1. ABT-737 is sensitive to HL60, KG1 and NB4 cells with IC50 of 50 nM, 80 nM and 80 nM, respectively. ABT-737 induces apoptosis in HL60 cells, which due to decreased Bcl-2/Bax heterodimerization and has no effect on cell cycle distribution. ABT-737 also induces cytochrome c release from purified mitochondria and promotes conformational changes in Bax that are associated with apoptosis. Resistant cells (Hela and MCF-7) can be sensitized to ABT-737 by approaches that down-regulate, destabilize, or inactivate Mcl-1. ABT-737 also causes Bax/BAK-dependent cytochrome c release only when Mcl-1 has been neutralized. ABT-737 displaces Bim from Bcl2's BH3-binding pocket, allowing Bim to activate Bax, induce mitochondrial permeabilization, and rapidly commit the primary chronic lymphocytic leukemia (CLL) cells to death. Knockdown of Mcl-1 with siRNA sensitizes two resistant SCLC cell lines H196 and DMS114 to ABT-737 by enhancing | ||
| 信号通路 | Apoptosis Pathway | ||
| 靶 点 | Bcl2 | ||
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ABT-737 Induces Bim Expression via JNK Signaling Pathway and Its Effect on the Radiation Sensitivity of HeLa Cells
购于瀚香生物(Biochempartner)的ABT-737(CAS:852808-04-9)被引用 |
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Norcantharidin combined with ABT-737 for hepatocellular carcinoma: Therapeutic effects and molecular mechanisms
购于瀚香生物(Biochempartner)的ABT-737(CAS:852808-04-9)被引用 |
结构式
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