甘氨鹅脱氧胆酸

  • 化学数据
CAS号 640-79-9 货号 BCP49686
中文名 甘氨鹅脱氧胆酸
英文名 Glycochenodeoxycholic acid
中文别名 甘鹅去氧胆酸;甘氨鹅去氧胆酸;
英文别名 GCDC;Glycochenodeoxycholate;Chenodeoxycholylglycine;Glycine chenodeoxycholate;
分子式 C26H43NO5 分子量 449.62
  • 用途
生物活性 Glycochenodeoxycholic acid is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC).
信号通路 Protease/Metabolic Enzyme Apoptosis Pathway 
靶 点 Caspase 

结构式

本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服:
全国免费电话:400-099-8200
在线客服:
技术支持:
orders@biochempartner.com
瀚香官网:
www.biochempartner.com
瀚香生物(Biochempartner) 的所有产品和服务仅用于科学研究,禁止用于人体和治疗!