Befotertinib

  • 化学数据
CAS号 1835667-63-4 货号 BCP49575
中文名 Befotertinib
英文名 Befotertinib
中文别名
英文别名 D-0316;D0316;D 0316;
分子式 C29H32F3N7O2 分子量 567.61
  • 用途
生物活性 Befotertinib is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. Upon administration, befotertinib specifically binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, which prevents EGFR-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. Compared to some other EGFR inhibitors, befotertinib may have therapeutic benefits in tumors with T790M-mediated drug resistance. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.
信号通路 Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway 
靶 点 EGFR 

结构式

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