奥那司酮
| CAS号 | 96346-61-1 | 货号 | BCP49272 |
| 中文名 | 奥那司酮 | ||
| 英文名 | Onapristone | ||
| 中文别名 | |||
| 英文别名 | IVV-1001; IVV 1001; IVV1001; ZK-98299; ZK-98299; ZK98299; | ||
| 分子式 | C29H39NO3 | 分子量 | 449.63 |
| 生物活性 | Onapristone is an orally bioavailable progesterone receptor (PR) antagonist, with potential antineoplastic activity. Upon oral administration, onapristone binds to the PR and inhibits both PR activation and the associated expression of PR-responsive genes. This may inhibit PR-mediated proliferative effects in cancer cells overexpressing PR. In addition, onapristone may downregulate cancer stem cell mobilization and block immune evasion. PR is expressed on certain cancer cell types and plays a key role in tumor cell proliferation and survival. | ||
| 信号通路 | Hormone Pathay | ||
| 靶 点 | Progesterone Receptor | ||
结构式
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