Dextromethadone

  • 化学数据
CAS号 5653-80-5 货号 BCP49227
中文名 Dextromethadone
英文名 Dextromethadone
中文别名
英文别名 Esmethadone;S-Methadone;
分子式 C21H27NO 分子量 309.4
  • 用途
生物活性 Dextromethadone is a 6-(dimethylamino)-4,4-diphenylheptan-3-one that has (S)-configuration. It is the less active enantiomer of methadone and has very little activity on opioid receptors and mainly responsible for the inhibition of hERG K+ channels and thus for cardiac toxicity. The drug is currently under clinical development for the treatment of major depressive disorder. It has a role as a NMDA receptor antagonist and an opioid analgesic. It is an enantiomer of a levomethadone.
信号通路 Ion Channel/Membrane Transporter 
靶 点 AMPA/NMDA 

结构式

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