JH-RE-06
| CAS号 | 1361227-90-8 | 货号 | BCP48872 |
| 中文名 | JH-RE-06 | ||
| 英文名 | JH-RE-06 | ||
| 中文别名 | |||
| 英文别名 | JH-RE06; JH-RE 06; JHRE-06; JHRE06; JHRE 06; | ||
| 分子式 | C20H16Cl3N3O4 | 分子量 | 468.72 |
| 生物活性 | JH-RE-06 is a potent REV1 inhibitor. JH-RE-06 disrupts mutagenic TLS by preventing recruitment of mutagenic POL ζ. JH-RE-06 targets a nearly featureless surface of REV1 that interacts with the REV7 subunit of POL ζ. JH-RE-06 inhibits mutagenic TLS and enhances cisplatin-induced toxicity in cultured human and mouse cell lines. Co-administration of JH-RE-06 with cisplatin suppresses the growth of xenograft human melanomas in mice, establishing a framework for developing TLS inhibitors as a novel class of chemotherapy adjuvants. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | DNA/RNA Synthesis | ||
结构式
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