KT-531
| CAS号 | 2490284-18-7 | 货号 | BCP48476 |
| 中文名 | KT-531 | ||
| 英文名 | KT-531 | ||
| 中文别名 | |||
| 英文别名 | KT531;KT 531; | ||
| 分子式 | C17H14F4N2O4S | 分子量 | 418.36 |
| 生物活性 | KT-531 is a potent, selective HDAC6 inhibitor with IC50 of 8.5 nM, displays 39-fold selectivity over other HDAC isoforms;KT-531 demonstrated biological potency in multiple hematological cancer cell models (acute myeloid leukemia (AML), PTCL, and T-cell acute lymphoblastic leukemia (T-ALL)) and limited cytotoxicity in nonmalignant cell types as well as no observable toxicity in vivo (CD-1 mice).KT-531 exhibited strong potency (IC50=0.42 μM) in the T-ALL/T-PLL-like cell line SUP-T11, demonstrated higher cytotoxicity than Nexturastat in MV4-11 cancer cells (IC50=0.42 uM versus 1.68 uM).KT-531 showed high synergy with chemotherapeutic agents idasanutlin, bendamustine, and venetoclax in T-PLL patient samples.KT-531 is the first HDAC6 inhibitor to show efficacy in T-PLL patient samples. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | HDAC | ||
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
- 全国免费电话：400-099-8200
- 在线客服:
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！