LY3143921
| CAS No. | 1627696-52-9 | Cat. No. | BCP48019 |
| Name | LY3143921 | ||
| Synonyms | LY-3143921;LY 3143921;(S)-LY3177833; | ||
| Formula | C16H12FN5O | M. Wt | 309.3 |
| Description | LY3143921 is a potent and selective CDC7 kinase inhibitor. LY3143921 targets, binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells. The serine-threonine kinase CDC7 plays a key role in DNA replication by binding to and phosphorylating serine (Ser)-40 and 53 of MCM2 (minichromosome maintenance complex component 2), which is required for the initiation of DNA replication. Although expressed at low levels in healthy, normal cells, CDC7 is expressed at much higher levels in cancer cells. | ||
| Related Products | 1627696-51-8（LY-3177833） 1627696-53-0（LY3143921 hydrate） | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | CDK | ||
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.