CDK12-IN-2
| CAS号 | 2244987-03-7 | 货号 | BCP46385 |
| 中文名 | CDK12-IN-2 | ||
| 英文名 | CDK12-IN-2 | ||
| 中文别名 | |||
| 英文别名 | CDK12 inhibitor 2; | ||
| 分子式 | C32H32N6O2 | 分子量 | 532.64 |
| 生物活性 | CDK12-IN-2 is a potent, selective and nanomolar CDK12 inhibitor (IC50=52 nM) with good physicochemical properties. CDK12-IN-2 is also a strong CDK13 inhibitor due to CDK13 is the closest homologue of CDK12. CDK12-IN-2 shows excellent kinase selectivity for CDK12 over CDK2, 9, 8, and 7. CDK12-IN-2 inhibits the phosphorylation of Ser2 in the C-terminal domain of RNA polymerase II. CDK12-IN-2 can be used an excellent chemical probe for functional studies of CDK12. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | CDK | ||
结构式
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