AZD4205
| CAS号 | 2091134-35-7 | 货号 | BCP46221 |
| 中文名 | AZD4205 | ||
| 英文名 | AZD4205 | ||
| 中文别名 | |||
| 英文别名 | JAK1-IN-4; AZD-4205; AZD 4205; | ||
| 分子式 | C26H32FN9O2 | 分子量 | 521.6 |
| 生物活性 | AZD4205 is a potent, selective JAK1 inhibitor IC50 of 73 nM and Ki of 2.8 nM, shows high selectivity against JAK2 and JAK3 with IC50 of 13,233 nM and >30,000 nM respectively; shows potent inhibition of p-STAT3 in a cell based assay of JAK1 activity with an IC50 of 128 nM and excellent selectivity across the kinome; reduces residual disease and prolongs the benefit of Osimertinib in lung cancer patients with EGFR activating mutations both in vitro and in vivo. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway Wnt/Stem Cell Epigenetics | ||
| 靶 点 | JAK | ||
结构式
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