CHR-3996

  • 化学数据
CAS号 1235859-13-8 货号 BCP44113
中文名 CHR-3996
英文名 CHR-3996
中文别名
英文别名 CHR3996;CHR 3996;
分子式 C21H20FN5O2 分子量 393.41
  • 用途
生物活性 CHR-3996 is an orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor CHR-3996 inhibits HDAC, resulting in an accumulation of highly acetylated histones, the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes; these events may result in the inhibition of tumor cell division and the induction of tumor cell apoptosis. This agent may upregulate HSP70 and downregulate anti-apoptotic Bcl-2 proteins more substantially than some first-generation HDAC inhibitors. HDACs, upregulated in many tumor cell types, are a family of metalloenzymes responsible for the deacetylation of chromatin histone proteins.
信号通路 Cell Cycle/DNA Damage 
靶 点 HDAC 

结构式

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