CHR-3996
CAS号 | 1235859-13-8 | 货号 | BCP44113 |
中文名 | CHR-3996 | ||
英文名 | CHR-3996 | ||
中文别名 | |||
英文别名 | CHR3996;CHR 3996; | ||
分子式 | C21H20FN5O2 | 分子量 | 393.41 |
生物活性 | CHR-3996 is an orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor CHR-3996 inhibits HDAC, resulting in an accumulation of highly acetylated histones, the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes; these events may result in the inhibition of tumor cell division and the induction of tumor cell apoptosis. This agent may upregulate HSP70 and downregulate anti-apoptotic Bcl-2 proteins more substantially than some first-generation HDAC inhibitors. HDACs, upregulated in many tumor cell types, are a family of metalloenzymes responsible for the deacetylation of chromatin histone proteins. | ||
信号通路 | Cell Cycle/DNA Damage | ||
靶 点 | HDAC |
结构式
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