MRK 560
| CAS No. | 677772-84-8 | Cat. No. | BCP43170 |
| Name | MRK 560 | ||
| Synonyms | MRK 560; MRK-560; | ||
| Formula | C19H17ClF5NO4S2 | M. Wt | 517.92 |
| Description | MRK 560 is a γ-secretase inhibitor, which selectively inhibits proteolytic cleavage of amyloid precursor protein (APP) over the Notch pathway. MRK 560 reduces levels of Aβ in vitro (inhibits Aβ40 and Aβ42 in SH-SY5Y neuroblastoma cells with an IC50 of 0.65 nM) and attenuates plaque deposition. This compound is orally bioavailable. | ||
| Pathways | Protease/Metabolic Enzyme Neuro Signaling Pathway Wnt/Stem Cell | ||
| Targets | Gamma secretase | ||
Structure
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