JNJ-63576253
| CAS号 | 2110428-64-1 | 货号 | BCP41266 |
| 中文名 | JNJ-63576253 | ||
| 英文名 | JNJ-63576253 | ||
| 中文别名 | |||
| 英文别名 | TRC253; TRC-253; TRC 253; JNJ63576253; JNJ 63576253; | ||
| 分子式 | C23H21F3N6O2S | 分子量 | 502.52 |
| 生物活性 | TRC253, also known as JNJ63576253, is a potent and orally active androgen receptor antagonist. TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus. This prevents binding to and transcription of AR-responsive genes, inhibits the expression of genes that regulate prostate cancer cell proliferation, and may lead to an inhibition of growth of tumor cells in which AR is overexpressed and/or mutated. AR is often overexpressed and/or mutated in prostate cancers and plays a key role in proliferation, survival and chemoresistance of tumor cells. | ||
| 信号通路 | Hormone Pathay | ||
| 靶 点 | Androgen Receptor | ||
结构式
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