U 18666A

  • 化学数据
CAS号 3039-71-2 货号 BCP41254
中文名 U 18666A
英文名 U 18666A
中文别名
英文别名 U 18666A; U18666A; U 18666 A; U-18666-A; NSC-70801; NSC 70801; NSC70801;
分子式 C25H42ClNO2 分子量 424.06
  • 用途
生物活性 U 18666A is an inhibitor of cholesterol synthesis. It acts by inhibiting desmosterol Δ24-reductase. U18666A inhibits classical swine fever virus replication through interference with intracellular cholesterol trafficking. U18666A or other cholesterol transport inhibitor may be considered as the antiviral drug for the treatment of cats with FIP. U18666A accumulated intracellular free cholesterol in the culture of normal medium but not cholesterol-free medium. U18666A also induced reactive oxygen species (ROS) generation in normal medium but much less in cholesterol-free medium.
信号通路 Protease/Metabolic Enzyme Microbiology/Virology 
靶 点 HCV Protease HCV 

结构式

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