DS-1206b
CAS号 | 1855860-24-0 | 货号 | BCP40272 |
中文名 | DS-1206b | ||
英文名 | DS-1206b | ||
中文别名 | |||
英文别名 | DS-1205; DS 1205; DS1205; DS-1205b; DS 1205b; DS1205b; | ||
分子式 | C41H42FN5O7 | 分子量 | 735.81 |
生物活性 | DS-1206b is a selective and potent AXL kinase inhibitor with IC50 of 1.3 nM. DS-1205 potently inhibited the hGAS6-induced migration in vitro with EC50 of 2.7 nM. DS-1205b monotherapy exerted significant antitumor activity in an NIH3T3-AXL allograft model. In an HCC827 xenograft model, combination treatment with DS-1205b and osimertinib significantly delayed on the onset of tumor resistance compared to osimertinib alone in a manner proportional to DS-1205b does. DS-1205b also showed a similar resistance delay effect with erlotinib combination in the same xenograft model. | ||
信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
靶 点 | TAM Receptor |
结构式
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