醋酸氟氢可的松

  • 化学数据
CAS号 514-36-3 货号 BCP38927
中文名 醋酸氟氢可的松
英文名 Fludrocortisone acetate
中文别名
英文别名 Fludrocortisone 21-acetate;
分子式 C23H31FO6 分子量 422.49
  • 用途
生物活性 Fludrocortisone Acetate is the acetate salt of a synthetic fluorinated corticosteroid with antiinflammatory and antiallergic activities. As a glucocorticoid-receptor agonist, fludrocortisone binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2 (PLA2). Inhibition of PLA2 activity prevents the release of arachidonic acid, a precursor of eicosanoids such as prostaglandins and leukotrienes; eicosanoids are important mediators in the pro-inflammatory response mechanism. As a mineralocorticoid-receptor agonist, this agent stimulates Na+ reabsorption and water retention and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney.
信号通路 GPCR/G Protein 
靶 点 Glucocorticoid Receptor 

结构式

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