醋酸氟氢可的松
CAS号 | 514-36-3 | 货号 | BCP38927 |
中文名 | 醋酸氟氢可的松 | ||
英文名 | Fludrocortisone acetate | ||
中文别名 | |||
英文别名 | Fludrocortisone 21-acetate; | ||
分子式 | C23H31FO6 | 分子量 | 422.49 |
生物活性 | Fludrocortisone Acetate is the acetate salt of a synthetic fluorinated corticosteroid with antiinflammatory and antiallergic activities. As a glucocorticoid-receptor agonist, fludrocortisone binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2 (PLA2). Inhibition of PLA2 activity prevents the release of arachidonic acid, a precursor of eicosanoids such as prostaglandins and leukotrienes; eicosanoids are important mediators in the pro-inflammatory response mechanism. As a mineralocorticoid-receptor agonist, this agent stimulates Na+ reabsorption and water retention and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney. | ||
信号通路 | GPCR/G Protein | ||
靶 点 | Glucocorticoid Receptor |
结构式
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