氢化可的松琥珀酸钠
| CAS号 | 125-04-2 | 货号 | BCP38923 |
| 中文名 | 氢化可的松琥珀酸钠 | ||
| 英文名 | Hydrocortisone sodium succinate | ||
| 中文别名 | 氢化可的松琥珀酸酯 钠盐;氢可琥钠; | ||
| 英文别名 | Hydrocortisone 21-hemisuccinate sodium salt; | ||
| 分子式 | C25H33NaO8 | 分子量 | 484.52 |
| 生物活性 | Hydrocortisone Sodium Succinate is the sodium salt of hydrocortisone succinate with glucocorticoid property. Hydrocortisone sodium succinate is chemically similar to the endogenous hormone that stimulates anti-inflammatory and immunosuppressive activities, in addition to exhibiting minor mineralocorticoid effects. This agent binds to intracellular glucocorticoid receptors and is translocated into the nucleus, where it initiates the transcription of glucocorticoid-responsive genes, such as various cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both potent mediators of inflammation. | ||
| 信号通路 | GPCR/G Protein | ||
| 靶 点 | Glucocorticoid Receptor | ||
结构式
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