R-1479
| CAS No. | 478182-28-4 | Cat. No. | BCP38817 |
| Name | R-1479 | ||
| Synonyms | R 1479; R1479; 4'-Azidocytidine; 4'-c-Azidocytidine; | ||
| Formula | C9H12N6O5 | M. Wt | 284.23 |
| Description | R-1479 is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture. R-1479 is a specific inhibitor of HCV replication in the HCV subgenomic replicon system (IC(50) = 1.28 microM). The corresponding 5'-triphosphate derivative (R1479-TP) is a potent inhibitor of native HCV replicase isolated from replicon cells and of recombinant HCV polymerase (NS5B)-mediated RNA synthesis activity. R1479-TP inhibited RNA synthesis as a CTP-competitive inhibitor with a K(i) of 40 nM. | ||
| Pathways | Microbiology/Virology | ||
| Targets | HCV | ||
Structure
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