雷西莫特盐酸盐

  • 化学数据
CAS号 1313757-36-6 货号 BCP38086
中文名 雷西莫特盐酸盐
英文名 Resiquimod HCl
中文别名
英文别名 R-848; R 848; R848; S 28463; S-28463; S28463; VML-600; VML600; VML 600;
分子式 C17H23ClN4O2 分子量 350.85
  • 用途
生物活性 Resiquimod is a n imidazoquinolinamine Toll-like receptor (TLR) agonist with potential immunostimulatory activity. Resiquimod binds to and activates TLRs 7 and 8, mainly on dendritic cells (DCs), macrophages, and B-lymphocytes, which results in the activation of the TLR signaling pathway and nuclear translocation of the transcription activator NF-kB another transcription factors; subsequently, the production of cytokines, especially interferon-alpha (INF-a), increases, enhancing T-helper 1 (Th1) immune responses. In addition, topical application of resiquimod appears to activate Langerhans cells, which may result in enhanced activation of T-lymphocytes.
信号通路 Others Pathway 
靶 点 TLR 

结构式

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