硫酸司美替尼
| CAS号 | 943332-08-9 | 货号 | BCP36547 |
| 中文名 | 硫酸司美替尼 | ||
| 英文名 | Selumetinib sulfate | ||
| 中文别名 | AZD6244硫酸盐;硫酸司美替尼; | ||
| 英文别名 | AZD-6244 sulfate;AZD 6244 sulfate;AZD6244 sulfate; ARRY-142886 sulfate; | ||
| 分子式 | C17H17BrClFN4O7S | 分子量 | 555.76 |
| 生物活性 | Selumetinib Sulfate is the sulfate salt of selumetinib, an orally active, small molecule with potential antineoplastic activity. Selumetinib is an ATP-independent inhibitor of mitogen-activated protein kinase kinase (MEK or MAPK/ERK kinase) 1 and 2. MEK 1 and 2 are dual specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway, are often upregulated in various cancer cells, and are drivers of diverse cellular responses, including proliferation. Inhibition of both MEK1 and 2 by selumetinib prevents the activation of MEK1/2 dependent effector proteins and transcription factors, thereby leading to an inhibition of cellular proliferation in various cancers. | ||
| 信号通路 | MAPK Pathway | ||
| 靶 点 | MEK/ERK | ||
结构式
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