Exatecan mesylate dihydrate

CAS No.	197720-53-9	Cat. No.	BCP36302
Name	Exatecan mesylate dihydrate
Synonyms	DX 8951; DX-8951; DX8951;
Formula	C25H32FN3O9S	M. Wt	567.58

Description	Exatecan Mesylate is a semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater potency than camptothecin and other camptothecin analogues.
Pathways	Cell Cycle/DNA Damage
Targets	Topoisomerase

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