S49076 HCl
| CAS号 | 1265965-19-2 | 货号 | BCP35053 |
| 中文名 | S49076 HCl | ||
| 英文名 | S49076 HCl | ||
| 中文别名 | |||
| 英文别名 | S49076 Hydrochloride;S 49076 HCl;S-49076 HCl; | ||
| 分子式 | C22H23ClN4O4S | 分子量 | 474.96 |
| 生物活性 | S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream signaling in vitro and in vivo. In cell models, S49076 inhibited the proliferation of MET- and FGFR2-dependent gastric cancer cells, blocked MET-driven migration of lung carcinoma cells, and inhibited colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL. In tumor xenograft models, a good pharmacokinetic/pharmacodynamic relationship for MET and FGFR2 inhibition following oral administration of S49076 was established and correlated well with impact on tumor growth. MET, AXL, and the FGFRs have all been implicated in resistance to VEGF/VEGFR inhibitors such as bevacizumab. A phase I study with S-49076 is currently underway in patients with advanced solid tumors. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | c Met FGFR | ||
结构式
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