Carboxyamidotriazole Orotate
| CAS No. | 187739-60-2 | Cat. No. | BCP34906 |
| Name | Carboxyamidotriazole Orotate | ||
| Synonyms | L-651582 Orotate; CAI Orotate; L 651582; L-651582; L651582; NSC 609974; NSC609974; NSC-609974; | ||
| Formula | C23H16Cl3IN7O6 | M. Wt | 580.76 |
| Description | Carboxyamidotriazole orotate is t he orotate salt form of carboxyamidotriazole (CAI), an orally bioavailable small molecule with potential antiangiogenic and antiproliferative activities. Carboxyamidotriazole binds to and inhibits non-voltage-operated calcium channels, blocking both Ca2+ influx into cells and Ca2+ release from intracellular stores, resulting in the disruption of calcium channel-mediated signal transduction. CAI inhibits PI3 activity and vascular endothelial growth factor (VEGF) signaling. This may inhibit endothelial proliferation, tumor cell growth, invasion and metastasis. | ||
| Pathways | Ion Channel/Membrane Transporter | ||
| Targets | Calcium Channel | ||
Structure
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