Phenoxodiol

  • Chemical Properties
CAS No. 81267-65-4 Cat. No. BCP34699
Name Phenoxodiol
Synonyms NV-06; NV06; NV 06; Dehydroequol; Idronoxil ; Haginin E;
Formula C15H12O3 M. Wt 240.25
  • Biological Activity
Description Phenoxodiol is a synthetic flavonoid derivative. Phenoxodiol activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis (XIAP), and disrupts FLICE inhibitory protein (FLIP) expression, resulting in tumor cell apoptosis. This agent also inhibits DNA topoisomerase II by stabilizing the cleavable complex, thereby preventing DNA replication and resulting in tumor cell death.
Pathways Cell Cycle/DNA Damage 
Targets Topoisomerase 

Structure

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