LMP744
  • 化学数据
CAS号 308246-52-8 货号 BCP34017
中文名 LMP744
英文名 LMP744
中文别名
英文别名 LMP-744; LMP 744; MJ-III-65; MJ-III65; NSC-706744;NSC 706744; NSC706744;
分子式 C24H24N2O7 分子量 452.46
  • 用途
生物活性 LMP744 is a DNA intercalator and topoisomerase inhibitor with antitumor activity. LMP744 produces persistent topoisomerase I cleavage complexes and overcome multidrug resistance. Consistent with Top1 poisoning, protein-linked DNA breaks were detected in cells treated with LMP744 at nanomolar concentrations. Studies in human cells in culture found LMP744 to be cytotoxic. Furthermore, limited cross-resistance was observed in camptothecin-resistant cell lines. LMP744 also exhibits antitumor activity in mouse tumor xenografts.
信号通路 Cell Cycle/DNA Damage 
靶 点 Topoisomerase 

结构式

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