SEN177
| CAS No. | 2117405-13-5 | Cat. No. | BCP33954 |
| Name | SEN177 | ||
| Synonyms | SEN 177;SEN-177; | ||
| Formula | C18H19FN6 | M. Wt | 338.38 |
| Description | SEN177 is a Glutaminyl cyclase (QPCT) inhibitor. Glutaminyl cyclase modifies N-terminal glutamine or glutamate residues to N-terminal 5-oxoproline or pyroglutamate (named QPCT). QPCT inhibits mutant huntingtin from forming aggregates, but also reduces aggregation of other aggregate-prone proteins containing polyQ or polyA repeats. SEN177 caused dose-dependent decreases in HTT aggregation by a mechanism that requires QPCT inhibition. SEN177 had in vitro activity against polyglutamine toxicity and was able to reduce aggregates in mammalian cells, primary neurons and in a Drosophila model. | ||
| Pathways | Neuro Signaling Pathway | ||
| Targets | Amyloid β | ||
Structure
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