UNC2541
CAS号 | 1612782-86-1 | 货号 | BCP33929 |
中文名 | UNC2541 | ||
英文名 | UNC2541 | ||
中文别名 | |||
英文别名 | UNC-2541; UNC 2541; | ||
分子式 | C24H34FN7O2 | 分子量 | 471.58 |
生物活性 | UNC2541 is a potent and MerTK-specific inhibitor that exhibits sub-micromolar inhibitory activity in the cell-based ELISA. In addition, an X-ray structure of MerTK protein in complex with 11 was resolved to show that these macrocycles bind in the MerTK ATP pocket. UNC2541 showed IC50 MerTH=4.4 nM; IC50 AXL = 120 nM; IC50 TYRO3 = 220 nM; IC50 FLT3 = 320 nM. | ||
信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
靶 点 | TAM Receptor |
结构式
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