洛索立宾

  • 化学数据
CAS号 121288-39-9 货号 BCP33260
中文名 洛索立宾
英文名 Loxoribine
中文别名 7-烯丙基-8-氧代鸟苷;
英文别名 7-Allyl-8-oxoguanosine;Loxoribina; Loxoribinum; RWJ-21757; RWJ 21757; RWJ21757;
分子式 C13H17N5O6 分子量 339.31
  • 用途
生物活性 Loxoribine is a guanine ribonucleotide derivative with immunostimulatory and immunomodulatory activity. Loxoribine undergoes facilitated transport across the plasma membrane into the cytoplasmic compartment of the cell and acts intracellularly, bypassing the biochemical steps involved in the membrane signal transduction pathway used by Ag or anti-IgM Abs to activate B cells. This agent activates the Toll-like receptor 7 (TLR7), a member of the TLR family of pathogen-associated molecular pattern recognition receptors thereby activating the innate immune system.
信号通路 Others Pathway 
靶 点 TLR 

结构式

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