GIBH-130

  • 化学数据
CAS号 1252608-59-5 货号 BCP32635
中文名 GIBH-130
英文名 GIBH-130
中文别名
英文别名 GIBH 130; GIBH130;
分子式 C20H20N6O 分子量 360.41
  • 用途
生物活性 GIBH-130 is a neuroinflammation inhibitor. GIBH-130 exhibited comparable in vivo efficacy of cognitive impairment relief to donepezil and memantine respectively in both β amyloid-induced and APP/PS1 double transgenic Alzheimer's murine models at a substantially lower dose (0.25 mg/kg). Therefore, GIBH-130 constitutes a unique chemical probe for pathogenesis research and drug development of AD, and it also suggests microglia-based phenotypic screenings that target neuroinflammation as an effective and feasible strategy to identify novel anti-AD agents.
信号通路 Others Pathway 
靶 点 Interleukin Related 

结构式

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