培米加替尼
| CAS号 | 1513857-77-6 | 货号 | BCP31812 |
| 中文名 | 培米加替尼 | ||
| 英文名 | Pemigatinib | ||
| 中文别名 | |||
| 英文别名 | INCB054828; INCB-054828; INCB 054828; INCB54828; INCB 54828; INCB-54828; | ||
| 分子式 | C24H27F2N5O4 | 分子量 | 487.5 |
| 生物活性 | Pemigatinib is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) types 1, 2, and 3 (FGFR1/2/3), with potential antineoplastic activity. Pemigatinib binds to and inhibits FGFR1/2/3, which may result in the inhibition of FGFR1/2/3-related signal transduction pathways. This inhibits proliferation in FGFR1/2/3-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases upregulated in many tumor cell types, plays a key role in cellular proliferation, migration, and survival. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | FGFR | ||
结构式
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