曲奥舒凡
| CAS号 | 299-75-2 | 货号 | BCP31509 |
| 中文名 | 曲奥舒凡 | ||
| 英文名 | Treosulfa | ||
| 中文别名 | |||
| 英文别名 | NSC 39069; NSC39069; NSC-39069;Treosulphan;Ovastat; | ||
| 分子式 | C6H14O8S2 | 分子量 | 278.301 |
| 生物活性 | Treosulfan is the product of a bifunctional sulfonate alkylating agent with myeloablative, immunosuppresive, and antineoplastic activities. Under physiological conditions, treosulfan converts nonenzymatically to L-diepoxybutane via a monoepoxide intermediate. The monoepoxide intermediate and L-diepoxybutane alkylate DNA at guanine residues and produce DNA interstrand crosslinks, resulting in DNA fragmentation and apoptosis. In escalated doses, this agent also exhbits myeloablative and immunosuppressive activities. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | DNA Alkylator/Crosslinker | ||
结构式
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